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Before starting treatment, people with these conditions should discuss the relative risks and benefits of treatment with their doctors to help determine if protriptyline is the right antidepressant for them.Trazodone may increase heart rate and stress on the heart.It may be dangerous to take trazodone in combination with these substances.Although lower in anticholinergic side effects than tricyclic antidepressants, trazodone should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urinary retention, and glaucoma, especially angle-closure glaucoma (the most severe form).In most patients, sedation decreases or disappears entirely with time, but until then patients taking trazodone should not perform hazardous activities requiring mental alertness or coordination, including driving and similar activities.

Therapy is usually started at a total of 150 mg per day divided into two or three doses.

It also shares some of the properties of selective serotonin reuptake inhibitor antidepressants ( fluoxetine , paroxetine , and sertraline ).

Trazodone is the most sedating, and least anticholinergic, of all the currently marketed antidepressants.

Trazodone is used to treat depression and to treat the combination of symptoms of anxiety and depression.

Like most antidepressants, trazodone has also been used in limited numbers of patients to treat panic disorder , obsessive-compulsive disorder , attention-deficit/hyperactivity disorder , enuresis (bed-wetting), eating disorders such as bulimia nervosa , cocaine dependency, and the depressive phase of bipolar (manic-depressive) disorder.

He is also a voting member of the IACUC and the director of DLAR. Duke University’s Division of Laboratory Animal Resources (DLAR) is a team of highly trained individuals dedicated to the humane care and use of animals in the Duke Animal Care and Use Program.

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